BRIEF COMMUNICATION Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies
نویسندگان
چکیده
Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies Graham Fairfoul, Lynne I. McGuire, Suvankar Pal, James W. Ironside, Juliane Neumann, Sharon Christie, Catherine Joachim, Margaret Esiri, Samuel G. Evetts, Michal Rolinski, Fahd Baig, Claudio Ruffmann, Richard Wade-Martins, Michele T. M. Hu, Laura Parkkinen & Alison J. E. Green The National CJD Research & Surveillance Unit, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom Centre for Clinical Brain Sciences, Western General Hospital, Edinburgh EH4 2XU, United Kingdom Oxford Parkinson’s Disease Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Level 6 West Wing, Oxford OX3 9DU, United Kingdom Oxford Project to Investigate Memory and Ageing (OPTIMA), Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Level 6 West Wing, Oxford OX3 9DU, United Kingdom Oxford Parkinson’s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, United Kingdom
منابع مشابه
Alpha‐synuclein RT‐QuIC in the CSF of patients with alpha‐synucleinopathies
We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with sensitivities of 92% and 95%, respectively, and wi...
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